I didn't think Lauaki went bad against Cas, but he certainly still doesn't look at the peak of physical fitness. With Clough, Crossley and Clark out though, I'd have him in the side. As much as I don't rate Mathers particularly, I do think he's our best choice at fullback. Thomas way too questionable defensively for my liking. I'm hoping Mathers tutoring Thomas will make him into a good player, but I'm not convinced he's there yet.
Assuming Welham, Williams, Purtell & Sidlow are back, and Jacks is available, I'd go with:
Mathers
Clare
Welham
Purtell
Williams
Gaskell
Addy
Kavanagh
O'Brien
Sidlow
Olbison
Pitts
Mellor
SUBS
Halafihi
Ferguson
2 of Haggerty, Walker & Lauaki
Kurt Haggerty can play prop as well as back row, so I can't decide which 2 of him, Lauaki and Walker I'd have on the bench. I'm not sure I've seen enough out of Walker to justify a place in the 17, especially since he's bound to be a penalty machine. Starting lineup picks itself for me at the moment though, only possible changes are starting Ferguson and putting one of the other back rows on the bench, and picking Caro ahead of one of the other wings. Personally, I think Clare & Williams are better players though.
(Edited to replace Jacks since it looks like he's off)